Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly

In mammals, the structural basis for the interaction between U1 and U2 small nuclear ribonucleoproteins (snRNPs) during the early steps of splicing is still elusive. The binding of the ubiquitin-like (UBL) domain of SF3A1 to the stem-loop 4 of U1 snRNP (U1-SL4) contributes to this interaction. Here,...

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Detalles Bibliográficos
Autores principales: de Vries, Tebbe, Martelly, William, Campagne, Sébastien, Sabath, Kevin, Sarnowski, Chris P., Wong, Jason, Leitner, Alexander, Jonas, Stefanie, Sharma, Shalini, Allain, Frédéric H.-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833184/
https://www.ncbi.nlm.nih.gov/pubmed/35101980
http://dx.doi.org/10.1073/pnas.2114092119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833184/
https://www.ncbi.nlm.nih.gov/pubmed/35101980
http://dx.doi.org/10.1073/pnas.2114092119

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