Mice expressing fluorescent PAR(2) reveal that endocytosis mediates colonic inflammation and pain

G protein–coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signaling of protease-activated receptor 2 (PAR(2)) in c...

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Detalles Bibliográficos
Autores principales: Latorre, Rocco, Hegron, Alan, Peach, Chloe J., Teng, Shavonne, Tonello, Raquel, Retamal, Jeffri S., Klein-Cloud, Rafael, Bok, Diana, Jensen, Dane D., Gottesman-Katz, Lena, Rientjes, Jeanette, Veldhuis, Nicholas A., Poole, Daniel P., Schmidt, Brian L., Pothoulakis, Charalabos H., Rankin, Carl, Xie, Ying, Koon, Hon Wai, Bunnett, Nigel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833192/
https://www.ncbi.nlm.nih.gov/pubmed/35110404
http://dx.doi.org/10.1073/pnas.2112059119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833192/
https://www.ncbi.nlm.nih.gov/pubmed/35110404
http://dx.doi.org/10.1073/pnas.2112059119

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