Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

The development of small-molecules targeting different components of SARS-CoV-2 is a key strategy to complement antibody-based treatments and vaccination campaigns in managing the COVID-19 pandemic. Here, we show that two thiol-based chemical probes that act as reducing agents, P2119 and P2165, inhi...

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Detalles Bibliográficos
Autores principales: Shi, Yunlong, Zeida, Ari, Edwards, Caitlin E., Mallory, Michael L., Sastre, Santiago, Machado, Matías R., Pickles, Raymond J., Fu, Ling, Liu, Keke, Yang, Jing, Baric, Ralph S., Boucher, Richard C., Radi, Rafael, Carroll, Kate S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833197/
https://www.ncbi.nlm.nih.gov/pubmed/35074895
http://dx.doi.org/10.1073/pnas.2120419119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833197/
https://www.ncbi.nlm.nih.gov/pubmed/35074895
http://dx.doi.org/10.1073/pnas.2120419119

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