Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells

The pentose phosphate pathway is a major source of NADPH for oxidative stress resistance in cancer cells but there is limited insight into its role in metastasis, when some cancer cells experience high levels of oxidative stress. To address this, we mutated the substrate binding site of glucose 6-ph...

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Detalles Bibliográficos
Autores principales: Aurora, Arin B., Khivansara, Vishal, Leach, Ashley, Gill, Jennifer G., Martin-Sandoval, Misty, Yang, Chendong, Kasitinon, Stacy Y., Bezwada, Divya, Tasdogan, Alpaslan, Gu, Wen, Mathews, Thomas P., Zhao, Zhiyu, DeBerardinis, Ralph J., Morrison, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833200/
https://www.ncbi.nlm.nih.gov/pubmed/35110412
http://dx.doi.org/10.1073/pnas.2120617119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833200/
https://www.ncbi.nlm.nih.gov/pubmed/35110412
http://dx.doi.org/10.1073/pnas.2120617119

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