Brain capillary obstruction during neurotoxicity in a mouse model of anti-CD19 chimeric antigen receptor T-cell therapy

Immunotherapy for haematologic malignancies with CD19-directed chimeric antigen receptor T cells has been highly successful at eradicating cancer but is associated with acute neurotoxicity in ∼40% of patients. This neurotoxicity correlates with systemic cytokine release syndrome, endothelial activat...

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Detalles Bibliográficos
Autores principales: Faulhaber, Lila D., Phuong, Anthea Q., Hartsuyker, Kendra Jae, Cho, Yeheun, Mand, Katie K., Harper, Stuart D., Olson, Aaron K., Garden, Gwenn A., Shih, Andy Y., Gust, Juliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833245/
https://www.ncbi.nlm.nih.gov/pubmed/35169706
http://dx.doi.org/10.1093/braincomms/fcab309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833245/
https://www.ncbi.nlm.nih.gov/pubmed/35169706
http://dx.doi.org/10.1093/braincomms/fcab309

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