Cargando…

Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets

SIMPLE SUMMARY: Currently, genomic databases offer a vast amount of information on mutational profiles and records of statistically significant genetic associations with diseases. However, the functional interpretation of frequently mutated genes implicated in cancer is essential for the development...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karagiannakos, Alexandros, Adamaki, Maria, Tsintarakis, Antonis, Vojtesek, Borek, Fåhraeus, Robin, Zoumpourlis, Vassilis, Karakostis, Konstantinos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833388/ https://www.ncbi.nlm.nih.gov/pubmed/35158934 http://dx.doi.org/10.3390/cancers14030664

Ejemplares similares

The Intricate Interplay between Cancer Stem Cells and Oncogenic miRNAs in Breast Cancer Progression and Metastasis
por: Tsintarakis, Antonis, et al.
Publicado: (2023)

DNA Methylation as a Diagnostic, Prognostic, and Predictive Biomarker in Head and Neck Cancer
por: Liouta, Galateia, et al.
Publicado: (2023)

DNA Damage Response Mechanisms in Head and Neck Cancer: Significant Implications for Therapy and Survival
por: Papalouka, Chara, et al.
Publicado: (2023)

The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer
por: Padariya, Monikaben, et al.
Publicado: (2022)

Shaping the regulation of the p53 mRNA tumour suppressor: the co-evolution of genetic signatures
por: Karakostis, Konstantinos, et al.
Publicado: (2019)

miRNA-Guided Regulation of Mesenchymal Stem Cells Derived from the Umbilical Cord: Paving the Way for Stem-Cell Based Regeneration and Therapy
por: Thomaidou, Arsinoe C., et al.
Publicado: (2023)

Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)
por: Pavlou, Ioannis A., et al.
Publicado: (2023)

Immunotherapy as a Precision Medicine Tool for the Treatment of Prostate Cancer
por: Adamaki, Maria, et al.
Publicado: (2021)

The p53 mRNA: an integral part of the cellular stress response
por: Haronikova, Lucia, et al.
Publicado: (2019)

CRISPR therapeutic tools for complex genetic disorders and cancer (Review)
por: Baliou, Stella, et al.
Publicado: (2018)

Role of the CRISPR system in controlling gene transcription and monitoring cell fate
por: Baliou, Stella, et al.
Publicado: (2018)

Biochemical pathways mediated by KLK6 protease in breast cancer
por: Pampalakis, Georgios, et al.
Publicado: (2019)

p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress
por: López, Ignacio, et al.
Publicado: (2017)

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs
por: Thomaidou, Arsinoe C., et al.
Publicado: (2022)

Targeting cancer metabolism in the era of precision oncology
por: Stine, Zachary E., et al.
Publicado: (2021)

ST6Gal1: Oncogenic signaling pathways and targets
por: GC, Sajina, et al.
Publicado: (2022)

Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in Oncology Via Regulating Oncogenic Signaling Pathways
por: Wu, Baokang, et al.
Publicado: (2021)

The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine
por: Jain, Saurabh, et al.
Publicado: (2016)

EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers
por: Wilson, Joanna B., et al.
Publicado: (2018)

Osteonecrosis of the jaw in the era of targeted therapy and immunotherapy in oncology
por: Nifosì, Antonio Fabrizio, et al.
Publicado: (2019)

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
por: Shih, Hung-Ju, et al.
Publicado: (2012)

Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling
por: Rai, Vivek, et al.
Publicado: (2012)

SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways
por: Bottino, Cinzia, et al.
Publicado: (2020)

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling
por: Nolan, Aoife A., et al.
Publicado: (2021)

Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma
por: Pokorna, Zuzana, et al.
Publicado: (2022)

The Wnt-dependent signaling pathways as target in oncology drug discovery
por: Janssens, Nico, et al.
Publicado: (2006)

Novel therapies emerging in oncology to target the TGF-β pathway
por: Kim, Byung-Gyu, et al.
Publicado: (2021)

DPS-2: A Novel Dual MEK/ERK and PI3K/AKT Pathway Inhibitor with Powerful Ex Vivo and In Vivo Anticancer Properties
por: Goulielmaki, Maria, et al.
Publicado: (2019)

Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
por: Song, Xiaowen, et al.
Publicado: (2015)

Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways
por: Lu, Haofeng, et al.
Publicado: (2022)

Protective role of taurine against oxidative stress
por: Baliou, Stella, et al.
Publicado: (2021)

Role of endothelial dysfunction in the severity of COVID-19 infection
por: Kadiyska, Tanya, et al.
Publicado: (2022)

Ameliorative effect of taurine against diabetes and renal-associated disorders (Review)
por: Baliou, Stella, et al.
Publicado: (2021)

FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target?
por: Lengyel, Csongor G., et al.
Publicado: (2022)

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
por: Jung, Bomi, et al.
Publicado: (2016)

Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
por: Yoshioka, Ema, et al.
Publicado: (2018)

Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems
por: Nair, Praful R.
Publicado: (2019)

The Oncogenic Effects, Pathways, and Target Molecules of JC Polyoma Virus T Antigen in Cancer Cells
por: Zheng, Hua-Chuan, et al.
Publicado: (2022)

The Sequence-specific Peptide-binding Activity of the Protein Sulfide Isomerase AGR2 Directs Its Stable Binding to the Oncogenic Receptor EpCAM
por: Mohtar, M. Aiman, et al.
Publicado: (2018)

Accurate and semi-automated reassociation of intermixed human skeletal remains recovered from bioarchaeological and forensic contexts
por: Anastopoulou, Ioanna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_15bg87nstnj22g6ng82qqqi4t4