Increased Activity of a NK-Specific CAR-NK Framework Targeting CD3 and CD5 for T-Cell Leukemias

SIMPLE SUMMARY: Chimeric antigen receptors (CAR) can redirect the activity of NK cells to target T-cell malignancies. Our results identify that recognition of CD5 molecules in malignant T cells by the CAR leads to improved antitumor response compared to targeting CD3, due to strong downregulation of...

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Detalles Bibliográficos
Autores principales: Voynova, Elisaveta, Hawk, Nga, Flomerfelt, Francis A., Telford, William G., Gress, Ronald E., Kanakry, Jennifer A., Kovalovsky, Damian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833462/
https://www.ncbi.nlm.nih.gov/pubmed/35158792
http://dx.doi.org/10.3390/cancers14030524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833462/
https://www.ncbi.nlm.nih.gov/pubmed/35158792
http://dx.doi.org/10.3390/cancers14030524

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