Germline Variants of CYBA and TRPM4 Predispose to Familial Colorectal Cancer

SIMPLE SUMMARY: Whole-genome sequencing and bioinformatics analysis on unique colorectal cancer families revealed two attractive candidate predisposition genes, CYBA and TRPM4, each with a loss-of-function variant. Supported by our functional studies, we suggest that the two gene defects mechanistic...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Lizhen, Miao, Beiping, Dymerska, Dagmara, Kuswik, Magdalena, Bueno-Martínez, Elena, Sanoguera-Miralles, Lara, Velasco, Eladio A., Paramasivam, Nagarajan, Schlesner, Matthias, Kumar, Abhishek, Yuan, Ying, Lubinski, Jan, Bandapalli, Obul Reddy, Hemminki, Kari, Försti, Asta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833488/
https://www.ncbi.nlm.nih.gov/pubmed/35158942
http://dx.doi.org/10.3390/cancers14030670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833488/
https://www.ncbi.nlm.nih.gov/pubmed/35158942
http://dx.doi.org/10.3390/cancers14030670

Ejemplares similares