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Germline Variants of CYBA and TRPM4 Predispose to Familial Colorectal Cancer

SIMPLE SUMMARY: Whole-genome sequencing and bioinformatics analysis on unique colorectal cancer families revealed two attractive candidate predisposition genes, CYBA and TRPM4, each with a loss-of-function variant. Supported by our functional studies, we suggest that the two gene defects mechanistic...

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Detalles Bibliográficos
Autores principales:	Zhu, Lizhen, Miao, Beiping, Dymerska, Dagmara, Kuswik, Magdalena, Bueno-Martínez, Elena, Sanoguera-Miralles, Lara, Velasco, Eladio A., Paramasivam, Nagarajan, Schlesner, Matthias, Kumar, Abhishek, Yuan, Ying, Lubinski, Jan, Bandapalli, Obul Reddy, Hemminki, Kari, Försti, Asta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833488/ https://www.ncbi.nlm.nih.gov/pubmed/35158942 http://dx.doi.org/10.3390/cancers14030670

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