Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types

SIMPLE SUMMARY: Ample evidence exists connecting dNTP pool dysregulation to cancer and genomic instability. SAMHD1, the unique dNTP triphosphohydrolase described in humans, has been proposed to play a key role in hematological cancers, although its value in advanced solid tumors has not yet been exp...

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Detalles Bibliográficos
Autores principales: Felip, Eudald, Gutiérrez-Chamorro, Lucía, Gómez, Maica, Garcia-Vidal, Edurne, Romeo, Margarita, Morán, Teresa, Layos, Laura, Pérez-Roca, Laia, Riveira-Muñoz, Eva, Clotet, Bonaventura, Fernandez, Pedro Luis, Mesía, Ricard, Martínez-Cardús, Anna, Ballana, Ester, Margelí, Mireia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833711/
https://www.ncbi.nlm.nih.gov/pubmed/35158911
http://dx.doi.org/10.3390/cancers14030641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833711/
https://www.ncbi.nlm.nih.gov/pubmed/35158911
http://dx.doi.org/10.3390/cancers14030641

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