Gene-Directed Enzyme/Prodrug Therapy of Rat Brain Tumor Mediated by Human Mesenchymal Stem Cell Suicide Gene Extracellular Vesicles In Vitro and In Vivo

SIMPLE SUMMARY: Extracellular vesicles— exosomes—secreted by human mesenchymal stem/stromal cells are able to cross the blood–brain barrier and internalize glioblastoma cells. We prepared exosomes possessing a gene message, the product of which is able to convert nontoxic 5-fluorocytosine to cytotox...

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Detalles Bibliográficos
Autores principales: Tibensky, Miroslav, Jakubechova, Jana, Altanerova, Ursula, Pastorakova, Andrea, Rychly, Boris, Baciak, Ladislav, Mravec, Boris, Altaner, Cestmir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833758/
https://www.ncbi.nlm.nih.gov/pubmed/35159002
http://dx.doi.org/10.3390/cancers14030735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833758/
https://www.ncbi.nlm.nih.gov/pubmed/35159002
http://dx.doi.org/10.3390/cancers14030735

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