MALAT1 Fusions and Basal Cells Contribute to Primary Resistance against Androgen Receptor Inhibition in TRAMP Mice

SIMPLE SUMMARY: We deeply characterized a frequently used mouse model of prostate cancer and found cellular and molecular regulators of resistance against antihormonal treatment, such as basal cell function and MALAT1 gene fusions. As these mechanisms also occur in human disease, our findings highli...

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Detalles Bibliográficos
Autores principales: Marhold, Maximilian, Udovica, Simon, Topakian, Thais, Horak, Peter, Horvat, Reinhard, Tomasich, Erwin, Heller, Gerwin, Krainer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833778/
https://www.ncbi.nlm.nih.gov/pubmed/35159020
http://dx.doi.org/10.3390/cancers14030749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833778/
https://www.ncbi.nlm.nih.gov/pubmed/35159020
http://dx.doi.org/10.3390/cancers14030749

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