Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth

Epigenetic deregulation plays an essential role in colorectal cancer progression. Bromodomains are epigenetic “readers” of histone acetylation. Bromodomain-containing protein 4 (BRD4) plays a pivotal role in transcriptional regulation and is a feasible drug target in cancer cells. Disease-specific e...

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Detalles Bibliográficos
Autores principales: Kondo, Hiroya, Mishiro, Kenji, Iwashima, Yuki, Qiu, Yujia, Kobayashi, Akiko, Lim, Keesiang, Domoto, Takahiro, Minamoto, Toshinari, Ogawa, Kazuma, Kunishima, Munetaka, Hazawa, Masaharu, Wong, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833887/
https://www.ncbi.nlm.nih.gov/pubmed/35159127
http://dx.doi.org/10.3390/cells11030317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833887/
https://www.ncbi.nlm.nih.gov/pubmed/35159127
http://dx.doi.org/10.3390/cells11030317

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