Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines

The inactivation of von Hippel–Lindau (VHL) is critical for clear cell renal cell carcinoma (ccRCC) and VHL syndrome. VHL loss leads to the stabilization of hypoxia-inducible factor α (HIFα) and other substrate proteins, which, together, drive various tumor-promoting pathways. There is inadequate mo...

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Detalles Bibliográficos
Autores principales: Wang, Xuechun, Hu, Jin, Fang, Yihao, Fu, Yanbin, Liu, Bing, Zhang, Chao, Feng, Shan, Lu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833913/
https://www.ncbi.nlm.nih.gov/pubmed/35159281
http://dx.doi.org/10.3390/cells11030472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833913/
https://www.ncbi.nlm.nih.gov/pubmed/35159281
http://dx.doi.org/10.3390/cells11030472

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