Imaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYC

SIMPLE SUMMARY: The transcription factor c-MYC drives growth and proliferation in most cancers. The c-MYC protein is short-lived and rapidly degraded. However, deubiquitinating enzymes can counteract its degradation and increase the levels of this oncogenic protein. We altered the expression of 41 i...

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Detalles Bibliográficos
Autores principales: Moree, Shannon E., Maneix, Laure, Iakova, Polina, Stossi, Fabio, Sahin, Ergun, Catic, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833929/
https://www.ncbi.nlm.nih.gov/pubmed/35159073
http://dx.doi.org/10.3390/cancers14030806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833929/
https://www.ncbi.nlm.nih.gov/pubmed/35159073
http://dx.doi.org/10.3390/cancers14030806

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