Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate

Oxidative stress caused by the exposure of pancreatic ß-cells to high levels of fatty acids impairs insulin secretion. This lipotoxicity is thought to play an important role in ß-cell failure in type 2 diabetes and can be prevented by antioxidants. Gamma-hydroxybutyrate (GHB), an endogenous antioxid...

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Detalles Bibliográficos
Autores principales: Yung, Justin Hou Ming, Yeung, Lucy Shu Nga, Ivovic, Aleksandar, Tan, Yao Fang, Jentz, Emelien Mariella, Batchuluun, Battsetseg, Gohil, Himaben, Wheeler, Michael B., Joseph, Jamie W., Giacca, Adria, Mamelak, Mortimer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833960/
https://www.ncbi.nlm.nih.gov/pubmed/35159354
http://dx.doi.org/10.3390/cells11030545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833960/
https://www.ncbi.nlm.nih.gov/pubmed/35159354
http://dx.doi.org/10.3390/cells11030545

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