Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes

Sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) is a crucial component of the cellular machinery responsible for Ca(2+) homeostasis. The selective inhibition of SERCA by thapsigargin (TG) leads to perturbations in Ca(2+) signaling, which can trigger endoplasmic reticulum (ER) stress. The unfolded...

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Detalles Bibliográficos
Autores principales: Pereira, Ana Catarina, Madeira, Nuno, Morais, Sofia, Macedo, António, Cruz, Maria Teresa, Pereira, Cláudia M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833979/
https://www.ncbi.nlm.nih.gov/pubmed/35159243
http://dx.doi.org/10.3390/cells11030433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833979/
https://www.ncbi.nlm.nih.gov/pubmed/35159243
http://dx.doi.org/10.3390/cells11030433

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