Genetic and Functional Differences between Duplicated Zebrafish Genes for Human SCN1A

There are currently seven different zebrafish strains that model Dravet Syndrome, a severe childhood form of epilepsy. These models are based on a set of duplicated genes, scn1laa and scn1lab, which are the homologs for human SCN1A. Disrupting one of the genes would mimic a heterozygous disease stat...

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Detalles Bibliográficos
Autores principales: Weuring, Wout J., Hoekman, Jos W., Braun, Kees P. J., Koeleman, Bobby P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834172/
https://www.ncbi.nlm.nih.gov/pubmed/35159264
http://dx.doi.org/10.3390/cells11030454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834172/
https://www.ncbi.nlm.nih.gov/pubmed/35159264
http://dx.doi.org/10.3390/cells11030454

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