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Genetic and Functional Differences between Duplicated Zebrafish Genes for Human SCN1A

There are currently seven different zebrafish strains that model Dravet Syndrome, a severe childhood form of epilepsy. These models are based on a set of duplicated genes, scn1laa and scn1lab, which are the homologs for human SCN1A. Disrupting one of the genes would mimic a heterozygous disease stat...

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Detalles Bibliográficos
Autores principales:	Weuring, Wout J., Hoekman, Jos W., Braun, Kees P. J., Koeleman, Bobby P. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834172/ https://www.ncbi.nlm.nih.gov/pubmed/35159264 http://dx.doi.org/10.3390/cells11030454

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