Multifaceted Analyses of Isolated Mitochondria Establish the Anticancer Drug 2-Hydroxyoleic Acid as an Inhibitor of Substrate Oxidation and an Activator of Complex IV-Dependent State 3 Respiration

The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) has been extensively investigated as a cancer therapy mainly based on its regulation of membrane lipid composition and structure, activating various cell fate pathways. We discovered, additionally, that 2OHOA can uncouple oxidative phosphorylation...

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Detalles Bibliográficos
Autores principales: Mishra, Kumudesh, Péter, Mária, Nardiello, Anna Maria, Keller, Guy, Llado, Victoria, Fernandez-Garcia, Paula, Kahlert, Ulf D., Barasch, Dinorah, Saada, Ann, Török, Zsolt, Balogh, Gábor, Escriba, Pablo V., Piotto, Stefano, Kakhlon, Or
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834245/
https://www.ncbi.nlm.nih.gov/pubmed/35159387
http://dx.doi.org/10.3390/cells11030578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834245/
https://www.ncbi.nlm.nih.gov/pubmed/35159387
http://dx.doi.org/10.3390/cells11030578

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