Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation

Chloride intracellular channel 4 (CLIC4) is a recently discovered driver of fibroblast activation in Scleroderma (SSc) and cancer-associated fibroblasts (CAF). CLIC4 expression and activity are regulated by TGF-β signalling through the SMAD3 transcription factor. In view of the aberrant activation o...

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Detalles Bibliográficos
Autores principales: Wasson, Christopher W., Caballero-Ruiz, Begoña, Gillespie, Justin, Derrett-Smith, Emma, Mankouri, Jamel, Denton, Christopher P., Canettieri, Gianluca, Riobo-Del Galdo, Natalia A., Del Galdo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834396/
https://www.ncbi.nlm.nih.gov/pubmed/35159339
http://dx.doi.org/10.3390/cells11030530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834396/
https://www.ncbi.nlm.nih.gov/pubmed/35159339
http://dx.doi.org/10.3390/cells11030530

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