Cargando…

Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation

Chloride intracellular channel 4 (CLIC4) is a recently discovered driver of fibroblast activation in Scleroderma (SSc) and cancer-associated fibroblasts (CAF). CLIC4 expression and activity are regulated by TGF-β signalling through the SMAD3 transcription factor. In view of the aberrant activation o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wasson, Christopher W., Caballero-Ruiz, Begoña, Gillespie, Justin, Derrett-Smith, Emma, Mankouri, Jamel, Denton, Christopher P., Canettieri, Gianluca, Riobo-Del Galdo, Natalia A., Del Galdo, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834396/ https://www.ncbi.nlm.nih.gov/pubmed/35159339 http://dx.doi.org/10.3390/cells11030530

Ejemplares similares

Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts
por: Wasson, Christopher W., et al.
Publicado: (2020)

Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability
por: Caballero-Ruiz, Begoña, et al.
Publicado: (2023)

Signaling Switching from Hedgehog-GLI to MAPK Signaling Potentially Serves as a Compensatory Mechanism in Melanoma Cell Lines Resistant to GANT-61
por: Piteša, Nikolina, et al.
Publicado: (2023)

Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
por: Riobo-Del Galdo, Natalia A., et al.
Publicado: (2019)

Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor
por: Liakouli, Vasiliki, et al.
Publicado: (2018)

From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling
por: Ghuloum, Fatmah I., et al.
Publicado: (2022)

Activation of the G(i) protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
por: Ho Wei, Lan, et al.
Publicado: (2018)

Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling
por: Morales-Alcala, Cintli C., et al.
Publicado: (2021)

Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G(13)
por: Guo, Xueshui, et al.
Publicado: (2018)

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility
por: Stakaitytė, Gabrielė, et al.
Publicado: (2018)

Type 1 interferon activation in systemic sclerosis: a biomarker, a target or the culprit
por: Kakkar, Vishal, et al.
Publicado: (2022)

SFRP4 Expression Is Linked to Immune-Driven Fibrotic Conditions, Correlates with Skin and Lung Fibrosis in SSc and a Potential EMT Biomarker
por: Tinazzi, Ilaria, et al.
Publicado: (2021)

GLI1 activates pro-fibrotic pathways in myelofibrosis fibrocytes
por: Manshouri, Taghi, et al.
Publicado: (2022)

PTCHD1 Binds Cholesterol but Not Sonic Hedgehog, Suggesting a Distinct Cellular Function
por: Hiltunen, Mimmu K., et al.
Publicado: (2023)

Economía de las colectividades indígenas colindantes con el lago Titicaca /
por: Galdo P., Raúl (Galdo Pagaza)
Publicado: (1962)

Placement of Dermal Regeneration Template on Fibrotic Dura
por: Leach, Garrison A, et al.
Publicado: (2020)

CPL Spectra of Camphor Derivatives in Solution by an Integrated QM/MD Approach
por: Del Galdo, Sara, et al.
Publicado: (2020)

The ONIOM/PMM Model for Effective Yet Accurate Simulation of Optical and Chiroptical Spectra in Solution: Camphorquinone in Methanol as a Case Study
por: Del Galdo, Sara, et al.
Publicado: (2020)

Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH
por: Wasson, Christopher W, et al.
Publicado: (2020)

Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts
por: Carvalheiro, Tiago, et al.
Publicado: (2020)

Alpinetin Suppresses Effects of TGF-β1 on Stimulating the Production and Organization of Fibrotic Markers in Human Primary Dermal Fibroblasts
por: Wikan, Nitwara, et al.
Publicado: (2022)

Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts
por: Lombardi, Francesca, et al.
Publicado: (2022)

Glibenclamide inhibits BK polyomavirus infection in kidney cells through CFTR blockade
por: Panou, Margarita-Maria, et al.
Publicado: (2020)

Vascular plant species diversity of Mt. Etna (Sicily): endemicity, insularity and spatial patterns along the altitudinal gradient of the highest active volcano in Europe
por: Sciandrello, Saverio, et al.
Publicado: (2020)

Contribution to the Orophilous Cushion-Like Vegetation of Central-Southern and Insular Greece
por: Musarella, Carmelo Maria, et al.
Publicado: (2020)

More to B: the growing evidence to inform targeting B cells in scleroderma
por: Bosello, Silvia Laura, et al.
Publicado: (2022)

Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines
por: Urdiciain, Alejandro, et al.
Publicado: (2021)

Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis
por: Ross, Rebecca L, et al.
Publicado: (2022)

Configurable Pseudo Noise Radar Imaging System Enabling Synchronous MIMO Channel Extension
por: Bräunlich, Niklas, et al.
Publicado: (2023)

Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts
por: Smaldone, Silvia, et al.
Publicado: (2011)

El indígena y el mestizo de Vilquechico /
por: Galdo Pagaza, Raúl
Publicado: (1962)

Tres áreas interculturales: Chupaca, Uripa y Capachica.
por: Galdo Lagaza, Raúl
Publicado: (1967)

Introducción a la sociedad y cultura andina del Perú
por: Galdo Pagaza, Raúl
Publicado: (1966)

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts
por: Shi-wen, Xu, et al.
Publicado: (2009)

Computational Spectroscopy in Solution by Integration of Variational and Perturbative Approaches on Top of Clusterized Molecular Dynamics
por: Mancini, Giordano, et al.
Publicado: (2020)

Automated quantification of 3D wound morphology by machine learning and optical coherence tomography in type 2 diabetes
por: Wang, Yinhai, et al.
Publicado: (2022)

Anti-fibrotic Potential of AT(2) Receptor Agonists
por: Wang, Yan, et al.
Publicado: (2017)

Differential Expression of Wound Fibrotic Factors between Facial and Trunk Dermal Fibroblasts
por: Kurita, Masakazu, et al.
Publicado: (2012)

Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites
por: Belgodere, Jorge A., et al.
Publicado: (2021)

Bituminaria antiatlantica (Psoraleeae, Fabaceae), a new species from Morocco
por: Brullo, Salvatore, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hkccafhf3rh5gfiq4elqegfea1