Deletion of Specific Conserved Motifs from the N-Terminal Domain of αB-Crystallin Results in the Activation of Chaperone Functions

Smaller oligomeric chaperones of α-crystallins (αA- and αB-) have received increasing attention due to their improved therapeutic potential in preventing protein aggregating diseases. Our previous study suggested that deleting 54–61 residues from the N-terminal domain (NTD) of αB-crystallin (αBΔ54–6...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahalingam, Sundararajan, Shankar, Goutham, Mooney, Brian P., Singh, Kamal, Santhoshkumar, Puttur, Sharma, Krishna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834691/
https://www.ncbi.nlm.nih.gov/pubmed/35163023
http://dx.doi.org/10.3390/ijms23031099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834691/
https://www.ncbi.nlm.nih.gov/pubmed/35163023
http://dx.doi.org/10.3390/ijms23031099

Ejemplares similares