2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

Inhibition of the human O-linked β-N-acetylglucosaminidase (hOGA, GH84) enzyme is pharmacologically relevant in several diseases such as neurodegenerative and cardiovascular disorders, type 2 diabetes, and cancer. Human lysosomal hexosaminidases (hHexA and hHexB, GH20) are mechanistically related en...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiss, Mariann, Timári, István, Barna, Teréz, Mészáros, Zuzana, Slámová, Kristýna, Bojarová, Pavla, Křen, Vladimír, Hayes, Joseph M., Somsák, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834866/
https://www.ncbi.nlm.nih.gov/pubmed/35162960
http://dx.doi.org/10.3390/ijms23031037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834866/
https://www.ncbi.nlm.nih.gov/pubmed/35162960
http://dx.doi.org/10.3390/ijms23031037

Ejemplares similares