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2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

Inhibition of the human O-linked β-N-acetylglucosaminidase (hOGA, GH84) enzyme is pharmacologically relevant in several diseases such as neurodegenerative and cardiovascular disorders, type 2 diabetes, and cancer. Human lysosomal hexosaminidases (hHexA and hHexB, GH20) are mechanistically related en...

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Detalles Bibliográficos
Autores principales:	Kiss, Mariann, Timári, István, Barna, Teréz, Mészáros, Zuzana, Slámová, Kristýna, Bojarová, Pavla, Křen, Vladimír, Hayes, Joseph M., Somsák, László
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834866/ https://www.ncbi.nlm.nih.gov/pubmed/35162960 http://dx.doi.org/10.3390/ijms23031037

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