Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains

Kynurenic acid (KYNA) is implicated in antiinflammatory processes in the brain through several cellular and molecular targets, among which microglia-related mechanisms are of paramount importance. In this study, we describe the effects of KYNA and one of its analogs, the brain-penetrable SZR104 (N-(...

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Detalles Bibliográficos
Autores principales: Szabo, Melinda, Lajkó, Noémi, Dulka, Karolina, Szatmári, István, Fülöp, Ferenc, Mihály, András, Vécsei, László, Gulya, Karoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835130/
https://www.ncbi.nlm.nih.gov/pubmed/35163002
http://dx.doi.org/10.3390/ijms23031079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835130/
https://www.ncbi.nlm.nih.gov/pubmed/35163002
http://dx.doi.org/10.3390/ijms23031079

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