Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells

Despite notable advances in utilising PARP inhibitor monotherapy, many cancers are not PARP inhibitor-sensitive or develop treatment resistance. In this work, we show that the two structurally-related sesquiterpene lactones, a 2-bromobenzyloxy derivative of dehydrosantonin (BdS) and alantolactone (A...

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Detalles Bibliográficos
Autores principales: Osborne, Hugh C., Larrosa, Igor, Schmidt, Christine K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835362/
https://www.ncbi.nlm.nih.gov/pubmed/35163037
http://dx.doi.org/10.3390/ijms23031116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835362/
https://www.ncbi.nlm.nih.gov/pubmed/35163037
http://dx.doi.org/10.3390/ijms23031116

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