MPP(+)-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition

The organic cation transporters OCT1-3 (SLC22A1-3) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and elimination. Their polyspecific nature makes OCTs highly susceptible to drug–drug interactions (DDIs). Currently, screening of OCT inhibi...

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Detalles Bibliográficos
Autores principales: Mocking, Tamara A. M., Sijben, Hubert J., Vermeulen, Yimé W., IJzerman, Adriaan P., Heitman, Laura H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835585/
https://www.ncbi.nlm.nih.gov/pubmed/35163125
http://dx.doi.org/10.3390/ijms23031203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835585/
https://www.ncbi.nlm.nih.gov/pubmed/35163125
http://dx.doi.org/10.3390/ijms23031203

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