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MPP(+)-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition
The organic cation transporters OCT1-3 (SLC22A1-3) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and elimination. Their polyspecific nature makes OCTs highly susceptible to drug–drug interactions (DDIs). Currently, screening of OCT inhibi...
Autores principales: | Mocking, Tamara A. M., Sijben, Hubert J., Vermeulen, Yimé W., IJzerman, Adriaan P., Heitman, Laura H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835585/ https://www.ncbi.nlm.nih.gov/pubmed/35163125 http://dx.doi.org/10.3390/ijms23031203 |
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