The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain

Krüppel-associated box (KRAB) zinc finger proteins are a large class of tetrapod transcription factors that usually exert transcriptional repression through recruitment of TRIM28/KAP1. The evolutionary root of modern KRAB domains (mKRAB) can be traced back to an ancestral motif (aKRAB) that occurs e...

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Detalles Bibliográficos
Autores principales: Lorenz, Peter, Steinbeck, Felix, Krause, Ludwig, Thiesen, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835667/
https://www.ncbi.nlm.nih.gov/pubmed/35162997
http://dx.doi.org/10.3390/ijms23031072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835667/
https://www.ncbi.nlm.nih.gov/pubmed/35162997
http://dx.doi.org/10.3390/ijms23031072

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