Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells

Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET proto-oncogene. We previously demonstrated that depletion of the mitochondrial molecular chaperone, mortalin, can effectively suppress human MTC cells in culture and in mouse xenografts, by disrupting m...

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Detalles Bibliográficos
Autores principales: Hong, Seung-Keun, Starenki, Dmytro, Johnson, Oleta T., Gestwicki, Jason E., Park, Jong-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835675/
https://www.ncbi.nlm.nih.gov/pubmed/35162987
http://dx.doi.org/10.3390/ijms23031063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835675/
https://www.ncbi.nlm.nih.gov/pubmed/35162987
http://dx.doi.org/10.3390/ijms23031063

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