Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress

Teriflunomide (TFN) limits relapses in relapsing–remitting multiple sclerosis (RRMS) by reducing lymphocytic proliferation through the inhibition of the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) and the subsequent modulation of de novo pyrimidine synthesis. Alterations of mitochondri...

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Detalles Bibliográficos
Autores principales: Malla, Bimala, Liotta, Agustin, Bros, Helena, Ulshöfer, Rebecca, Paul, Friedemann, Hauser, Anja E., Niesner, Raluca, Infante-Duarte, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835718/
https://www.ncbi.nlm.nih.gov/pubmed/35163469
http://dx.doi.org/10.3390/ijms23031538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835718/
https://www.ncbi.nlm.nih.gov/pubmed/35163469
http://dx.doi.org/10.3390/ijms23031538

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