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The K(+)-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms
Eukarya pyruvate kinases possess glutamate at position 117 (numbering of rabbit muscle enzyme), whereas bacteria have either glutamate or lysine. Those with E117 are K(+)-dependent, whereas those with K117 are K(+)-independent. In a phylogenetic tree, 80% of the sequences with E117 are occupied by T...
Autores principales: | Ramírez-Silva, Leticia, Hernández-Alcántara, Gloria, Guerrero-Mendiola, Carlos, González-Andrade, Martin, Rodríguez-Romero, Adela, Rodríguez-Hernández, Annia, Lugo-Munguía, Alan, Gómez-Coronado, Paul A., Rodríguez-Méndez, Cristina, Vega-Segura, Alicia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835810/ https://www.ncbi.nlm.nih.gov/pubmed/35163274 http://dx.doi.org/10.3390/ijms23031347 |
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