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The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT

RTK KIT regulates a variety of crucial cellular processes via its cytoplasmic domain (CD), which is composed of the tyrosine kinase domain, crowned by the highly flexible domains—the juxtamembrane region, kinase insertion domain, and C-tail, which are key recruitment regions for downstream signallin...

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Detalles Bibliográficos
Autores principales: Ledoux, Julie, Trouvé, Alain, Tchertanov, Luba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835827/
https://www.ncbi.nlm.nih.gov/pubmed/35163518
http://dx.doi.org/10.3390/ijms23031589