THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

Multiple myeloma (MM) is a hematological disease marked by abnormal growth of B cells in bone marrow. Inherent chromosomal instability and DNA damage are major hallmarks of MM, which implicates an aberrant DNA repair mechanism. Studies have implicated a role for CDK12 in the control of expression of...

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Detalles Bibliográficos
Autores principales: Shyamsunder, Pavithra, Sridharan, Shree Pooja, Madan, Vikas, Dakle, Pushkar, Zeya, Cao, Kanojia, Deepika, Chng, Wee-Joo, Ong, S. Tiong, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835885/
https://www.ncbi.nlm.nih.gov/pubmed/35163134
http://dx.doi.org/10.3390/ijms23031207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835885/
https://www.ncbi.nlm.nih.gov/pubmed/35163134
http://dx.doi.org/10.3390/ijms23031207

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