SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration

The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a gene-independent approach. Mitochondrial dysfunction and axon degeneration are common f...

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Detalles Bibliográficos
Autores principales: Finnegan, Laura K., Chadderton, Naomi, Kenna, Paul F., Palfi, Arpad, Carty, Michael, Bowie, Andrew G., Millington-Ward, Sophia, Farrar, G. Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835928/
https://www.ncbi.nlm.nih.gov/pubmed/35163535
http://dx.doi.org/10.3390/ijms23031606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835928/
https://www.ncbi.nlm.nih.gov/pubmed/35163535
http://dx.doi.org/10.3390/ijms23031606

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