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Evaluation of the Impact of Esterases and Lipases from the Circulatory System against Substrates of Different Lipophilicity
Esterases and lipases can process amphiphilic esters used as drugs and prodrugs and impact their pharmacokinetics and biodistribution. These hydrolases can also process ester components of drug delivery systems (DDSs), thus triggering DDSs destabilization with premature cargo release. In this study...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836011/ https://www.ncbi.nlm.nih.gov/pubmed/35163184 http://dx.doi.org/10.3390/ijms23031262 |