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Insights to Human γD-Crystallin Unfolding by NMR Spectroscopy and Molecular Dynamics Simulations

Human γD-crystallin (HGDC) is an abundant lens protein residing in the nucleus of the human lens. Aggregation of this and other structural proteins within the lens leads to the development of cataract. Much has been explored on the stability and aggregation of HGDC and where detailed investigation a...

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Detalles Bibliográficos
Autores principales: Hsueh, Shu-Shun, Wang, S.-S. (Steven), Chen, Shu-Han, Wang, Chia-Lin, Wu, W. (Josephine), Lin, Ta-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836049/
https://www.ncbi.nlm.nih.gov/pubmed/35163513
http://dx.doi.org/10.3390/ijms23031591