The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse

The proteins from the Fanconi Anemia (FA) pathway of DNA repair maintain DNA replication fork integrity by preventing the unscheduled degradation of nascent DNA at regions of stalled replication forks. Here, we ask if the bacterial pathogen H. pylori exploits the fork stabilisation machinery to gene...

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Detalles Bibliográficos
Autores principales: Kolinjivadi, Arun Mouli, Sankar, Haresh, Choudhary, Ramveer, Tay, Lavina Sierra, Tan, Tuan Zea, Murata-Kamiya, Naoko, Voon, Dominic Chih-Cheng, Kappei, Dennis, Hatakeyama, Masanori, Krishnan, Vaidehi, Ito, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836099/
https://www.ncbi.nlm.nih.gov/pubmed/35163588
http://dx.doi.org/10.3390/ijms23031661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836099/
https://www.ncbi.nlm.nih.gov/pubmed/35163588
http://dx.doi.org/10.3390/ijms23031661

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