Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs

Spinocerebellar ataxia type 3 (SCA3) is characterized by the over-repetitive CAG codon in the ataxin-3 gene (ATXN3), which encodes the mutant ATXN3 protein. The pathological defects of SCA3 such as the impaired aggresomes, autophagy, and the proteasome have been reported previously. To date, no effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hsin-Han, Chiang, I-Tsang, Liu, Jen-Wei, Hsieh, Jeanne, Lee, Jui-Hao, Lu, Huai-En, Tso, Hwa-Sung, Deng, Yu-Chen, Kao, Jo-Chi, Wu, Jhen-Rong, Harn, Horng-Jyh, Chiou, Tzyy-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836169/
https://www.ncbi.nlm.nih.gov/pubmed/35163312
http://dx.doi.org/10.3390/ijms23031391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836169/
https://www.ncbi.nlm.nih.gov/pubmed/35163312
http://dx.doi.org/10.3390/ijms23031391

Ejemplares similares