Cargando…
Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs
Spinocerebellar ataxia type 3 (SCA3) is characterized by the over-repetitive CAG codon in the ataxin-3 gene (ATXN3), which encodes the mutant ATXN3 protein. The pathological defects of SCA3 such as the impaired aggresomes, autophagy, and the proteasome have been reported previously. To date, no effe...
Autores principales: | Yang, Hsin-Han, Chiang, I-Tsang, Liu, Jen-Wei, Hsieh, Jeanne, Lee, Jui-Hao, Lu, Huai-En, Tso, Hwa-Sung, Deng, Yu-Chen, Kao, Jo-Chi, Wu, Jhen-Rong, Harn, Horng-Jyh, Chiou, Tzyy-Wen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836169/ https://www.ncbi.nlm.nih.gov/pubmed/35163312 http://dx.doi.org/10.3390/ijms23031391 |
Ejemplares similares
-
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
por: Lee, Jui-Hao, et al.
Publicado: (2021) -
N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model
por: Yang, Hsin-Han, et al.
Publicado: (2020) -
The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
por: Chuang, Hong-Meng, et al.
Publicado: (2016) -
n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
por: Yen, Ssu-Yin, et al.
Publicado: (2017) -
Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
por: Chuang, Hong-Meng, et al.
Publicado: (2018)