Cargando…

Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways

Calycosin, a bioactive isoflavonoid isolated from root extracts of Astragalus membranaceus, has been reported to inhibit melanogenesis, the mechanism of which remains undefined. In this study, we interrogated the mechanistic basis by which calycosin inhibits melanin production in two model systems,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Kun-Chang, Hseu, You-Cheng, Shih, Yu-Ching, Sivakumar, Govindan, Syu, Jyun-Ting, Chen, Guan-Lin, Lu, Meng-Tien, Chu, Po-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836186/ https://www.ncbi.nlm.nih.gov/pubmed/35163281 http://dx.doi.org/10.3390/ijms23031358

Ejemplares similares

Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways
por: Lee, Seung Eun, et al.
Publicado: (2018)

Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways
por: Hwang, Young Sun, et al.
Publicado: (2019)

SNA077, an Extract of Marine Streptomyces sp., Inhibits Melanogenesis by Downregulating Melanogenic Proteins via Inactivation of cAMP/PKA/CREB Signaling
por: Lim, Su-Jin, et al.
Publicado: (2022)

6-Methylcoumarin Promotes Melanogenesis through the PKA/CREB, MAPK, AKT/PI3K, and GSK3β/β-Catenin Signaling Pathways
por: Kim, Taejin, et al.
Publicado: (2023)

Protocatechuic Aldehyde Inhibits α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells via PKA/CREB-Associated MITF Downregulation
por: Ko, Seok-Chun, et al.
Publicado: (2021)

Bamboo Lignin Fractions with In Vitro Tyrosinase Inhibition Activity Downregulate Melanogenesis in B16F10 Cells via PKA/CREB Signaling Pathway
por: Choi, Moon-Hee, et al.
Publicado: (2022)

Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways
por: Uto, Takuhiro, et al.
Publicado: (2019)

Syntenin regulates melanogenesis via the p38 MAPK pathway
por: Sun, Lijun, et al.
Publicado: (2020)

Anti-Melanogenic Effects of Lilium lancifolium Root Extract via Downregulation of PKA/CREB and MAPK/CREB Signaling Pathways in B16F10 Cells
por: Park, Seokmuk, et al.
Publicado: (2023)

Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKA/CREB/MITF Signaling
por: Lin, Mao, et al.
Publicado: (2014)

Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway
por: Choi, Moon-Hee, et al.
Publicado: (2022)

Supercritical Fluid Extract of Spent Coffee Grounds Attenuates Melanogenesis through Downregulation of the PKA, PI3K/Akt, and MAPK Signaling Pathways
por: Huang, Huey-Chun, et al.
Publicado: (2016)

Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway
por: Gao, Rongyin, et al.
Publicado: (2023)

Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling
por: Choi, Mi Ran, et al.
Publicado: (2022)

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin
por: Kim, Taejin, et al.
Publicado: (2022)

Atraric Acid Ameliorates Hyperpigmentation through the Downregulation of the PKA/CREB/MITF Signaling Pathway
por: Li, Jing, et al.
Publicado: (2022)

Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
por: Wang, Heng, et al.
Publicado: (2023)

Fermented Aronia melanocarpa Inhibits Melanogenesis through Dual Mechanisms of the PI3K/AKT/GSK-3β and PKA/CREB Pathways
por: Kim, Da Hee, et al.
Publicado: (2023)

Miglitol, an Oral Antidiabetic Drug, Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA, MAPK, and GSK3β/β-Catenin Signaling Pathways
por: Kim, Hyeon-Mi, et al.
Publicado: (2022)

The PKA-CREB system encoded by the honeybee genome
por: Eisenhardt, D, et al.
Publicado: (2006)

Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells
por: Seong, Zuh-Kyung, et al.
Publicado: (2016)

Calycosin induces apoptosis via p38-MAPK pathway-mediated activation of the mitochondrial apoptotic pathway in human osteosarcoma 143B cells
por: Tian, Wei, et al.
Publicado: (2020)

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
por: Kandel, Eric R
Publicado: (2012)

Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis
por: Li, Jiaxin, et al.
Publicado: (2017)

Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB
por: Quan, Gui-Hua, et al.
Publicado: (2015)

p38 MAPK regulates PKAα and CUB-serine protease in Amphibalanus amphitrite cyprids
por: Zhang, Gen, et al.
Publicado: (2015)

Complex roles of cAMP–PKA–CREB signaling in cancer
por: Zhang, Hongying, et al.
Publicado: (2020)

Rottlerin Reduces cAMP/CREB-Mediated Melanogenesis via Regulation of Autophagy
por: Qomaladewi, Nurinanda Prisky, et al.
Publicado: (2019)

Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways
por: Kang, Su Jin, et al.
Publicado: (2015)

Attenuation of melanogenesis by Nymphaea nouchali (Burm. f) flower extract through the regulation of cAMP/CREB/MAPKs/MITF and proteasomal degradation of tyrosinase
por: Alam, Md Badrul, et al.
Publicado: (2018)

Calycosin Suppresses Breast Cancer Cell Growth via ERβ-Dependent Regulation of IGF-1R, p38 MAPK and PI3K/Akt Pathways
por: Chen, Jian, et al.
Publicado: (2014)

Discovery of Pinostrobin as a Melanogenic Agent in cAMP/PKA and p38 MAPK Signaling Pathway
por: Yoon, Jeong-Hyun, et al.
Publicado: (2022)

Tobramycin Promotes Melanogenesis by Upregulating p38 MAPK Protein Phosphorylation in B16F10 Melanoma Cells
por: Moon, Seung-Hyun, et al.
Publicado: (2019)

Nypa fruticans Wurmb inhibits melanogenesis in isobutylmethylxanthine‑treated melanoma via the PI3K/AKT/mTOR/CREB and MAPK signaling pathways
por: Han, So-Yeon, et al.
Publicado: (2022)

Silver Carp (Hypophthalmichthys molitrix) Scale Collagen Peptides-1 (SCPs1) Inhibit Melanogenesis through Downregulation of the cAMP-CREB Signaling Pathway
por: Li, Hai-Lan, et al.
Publicado: (2023)

Phoenix dactylifera L. Seed Extract Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16F10 Murine Melanoma Cells by Downregulating PKA Signaling
por: Huang, Huey-Chun, et al.
Publicado: (2020)

PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
por: Xue, Wenda, et al.
Publicado: (2016)

Flumequine-Mediated Upregulation of p38 MAPK and JNK Results in Melanogenesis in B16F10 Cells and Zebrafish Larvae
por: Karunarathne, Wisurumuni Arachchilage Hasitha Maduranga, et al.
Publicado: (2019)

Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia
por: Han, Xin-Rui, et al.
Publicado: (2018)

Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1: Calycosin inhibits breast cancer growth by regulating HOTAIR
por: Li, Yuhong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_12u5jledbble45pi0cqoob39n7