Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 regulate the lymph node homing of dendritic cells and naïve T-cells and the following induction of a motile DC-T cell priming state. Although CCL19 and CCL21 bind CCR7 with similar affinities, CCL21 is a weak agonist compared to CCL19. Usin...

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Detalles Bibliográficos
Autores principales: Brandum, Emma Probst, Jørgensen, Astrid Sissel, Calvo, Marina Barrio, Spiess, Katja, Peterson, Francis C., Yang, Zhang, Volkman, Brian F., Veldkamp, Christopher T., Rosenkilde, Mette Marie, Goth, Christoffer Knak, Hjortø, Gertrud Malene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836243/
https://www.ncbi.nlm.nih.gov/pubmed/35163323
http://dx.doi.org/10.3390/ijms23031397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836243/
https://www.ncbi.nlm.nih.gov/pubmed/35163323
http://dx.doi.org/10.3390/ijms23031397

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