Cargando…

Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2

This study aimed to identify potential inhibitors and investigate the mechanism of action on SARS-CoV-2 ACE2 receptors using a molecular modeling study and theoretical determination of biological activity. Hydroxychloroquine was used as a pivot structure and antimalarial analogues of 1,2,4,5 tetraox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramos, Ryan S., Borges, Rosivaldo S., de Souza, João S. N., Araujo, Inana F., Chaves, Mariana H., Santos, Cleydson B. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836247/ https://www.ncbi.nlm.nih.gov/pubmed/35163703 http://dx.doi.org/10.3390/ijms23031781

Ejemplares similares

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani
por: Cabral, Lília I. L., et al.
Publicado: (2020)

1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action
por: Mendes, Andreia, et al.
Publicado: (2022)

5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents
por: Jansongsaeng, Somruedee, et al.
Publicado: (2021)

Complete Clearance of Cutaneous Warts with Hydroxychloroquine: Antiviral Action?
por: Bhushan, Premanshu, et al.
Publicado: (2014)

Reproductive toxicology. 1,2,4,5-Tetrachlorobenzene.
Publicado: (1997)

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
por: O'Neill, Paul M., et al.
Publicado: (2017)

1,2,4,5-Tetramethyl-3,6-diphenyl-1,2,4,5-tetraaza-3,6-diphosphinane
por: Kriel, Frederik H., et al.
Publicado: (2008)

Interaction between the Antimalarial Drug Dispiro-Tetraoxanes and Human Serum Albumin: A Combined Study with Spectroscopic Methods and Computational Studies
por: Yadav, Priyanka, et al.
Publicado: (2020)

Exploration of High‐Energy‐Density Materials: Computational Insight into Energetic Derivatives Based on 1,2,4,5‐Tetrahydro‐1,2,4,5‐tetrazine
por: Jin, Xinghui, et al.
Publicado: (2018)

Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies
por: Hassan, Aisha Y., et al.
Publicado: (2023)

Corrigendum: Exploration of High‐Energy‐Density Materials: Computational Insight into Energetic Derivatives Based on 1,2,4,5‐Tetrahydro‐1,2,4,5‐tetrazine
por: Jin, Xinghui, et al.
Publicado: (2019)

1,2,4,5-Tetraphenyl-1H-imidazole
por: Zhao, Bing, et al.
Publicado: (2012)

Monoclinic form of 1,2,4,5-tetracyclohexylbenzene
por: Mague, Joel T., et al.
Publicado: (2008)

Triclinic form of 1,2,4,5-tetracyclohexylbenzene
por: Mague, Joel T., et al.
Publicado: (2008)

The interplay between miR-1245a and BRCA2 in colorectal cancer
por: Scorilas, Andreas, et al.
Publicado: (2020)

Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro
por: Silva, Rai C., et al.
Publicado: (2021)

3-Phenyl-6-(2-pyridyl)-1,2,4,5-tetrazine
por: Chartrand, Daniel, et al.
Publicado: (2007)

Mapping the polymorphic transformation gateway vibration in crystalline 1,2,4,5-tetrabromobenzene
por: Zaczek, Adam J., et al.
Publicado: (2018)

Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues
por: Shukla, Ashutosh M, et al.
Publicado: (2019)

Hydroxychloroquine: mechanism of action inhibiting SARS-CoV2 entry.
por: Yuan, Zixuan, et al.
Publicado: (2020)

Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids against SARS-CoV-2
por: Faísca, Francisco, et al.
Publicado: (2022)

Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity
por: Andreeva, Olga V., et al.
Publicado: (2020)

Bis(piperazinediium) benzene-1,2,4,5-tetracarboxylate hexahydrate
por: Aghabozorg, Hossein, et al.
Publicado: (2008)

Cyclopropenes for the Stepwise Synthesis of 1,2,4,5-Tetraarylbenzenes via 1,4-Cyclohexadienes
por: Kishida, Satoshi, et al.
Publicado: (2022)

Synthesis and radiolabeling of a polar [(125)I]I‐1,2,4,5‐tetrazine
por: Bidesi, Natasha, et al.
Publicado: (2022)

Bis(propane-1,2-diammonium) benzene-1,2,4,5-tetracarboxylate dihydrate
por: Pasdar, Hoda, et al.
Publicado: (2010)

Transcriptomic dataset of Mycolicibacterium smegmatis exposed to an imidazo[1,2-b][1,2,4,5]tetrazine
por: Vatlin, Aleksey A., et al.
Publicado: (2020)

Advances in antiviral nucleoside analogues and their prodrugs
por: Seley-Radtke, Katherine, et al.
Publicado: (2018)

Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
por: dos Santos, Kelton L. B., et al.
Publicado: (2020)

Hierarchical Virtual Screening Based on Rocaglamide Derivatives to Discover New Potential Anti-Skin Cancer Agents
por: dos Santos, Igor V.F., et al.
Publicado: (2022)

Poly[(μ-benzene-1,2,4,5-tetracarboxylato)tetrasilver(I)]
por: Tahir, M. Nawaz, et al.
Publicado: (2009)

Potential Roles of miRNA-1245a Regulatory Networks in Sarcopenia
por: An, Li, et al.
Publicado: (2021)

Bis(tetramethylamonium) bis(2,4,5-carboxybenzoate)–benzene-1,2,4,5-tetracarboxylic acid (1/1)
por: Cunha-Silva, Luís, et al.
Publicado: (2007)

Hydroxychloroquine in COVID-19: Potential Mechanism of Action Against SARS-CoV-2
por: Satarker, Sairaj, et al.
Publicado: (2020)

Antiviral Activities of Oleanolic Acid and Its Analogues
por: Khwaza, Vuyolwethu, et al.
Publicado: (2018)

Broad-Spectrum Antiviral Strategies and Nucleoside Analogues
por: Geraghty, Robert J., et al.
Publicado: (2021)

Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism
por: Borges, Rosivaldo S., et al.
Publicado: (2019)

In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection
por: Braz, Helyson Lucas Bezerra, et al.
Publicado: (2020)

Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach
por: Leão, Rozires P., et al.
Publicado: (2020)

Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2
por: Uzunova, Katya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lehfk2d991pth5dr5ao7ogum4c