Acidic pH reduces agonist efficacy and responses to synaptic‐like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors

ABSTRACT: Many pentameric ligand‐gated ion channels are modulated by extracellular pH. Glycine receptors (GlyRs) share this property, but it is not well understood how they are affected by pH changes. Whole cell experiments on HEK293 cells expressing zebrafish homomeric α1 GlyR confirmed previous re...

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Detalles Bibliográficos
Autores principales: Ivica, Josip, Lape, Remigijus, Sivilotti, Lucia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Molecular and Cellular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836455/
https://www.ncbi.nlm.nih.gov/pubmed/34802146
http://dx.doi.org/10.1113/JP282171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836455/
https://www.ncbi.nlm.nih.gov/pubmed/34802146
http://dx.doi.org/10.1113/JP282171

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