Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence

People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates inflammatory cell adhesion proteins on endothelial cells and circulating ce...

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Detalles Bibliográficos
Autores principales: Gentinetta, Thomas, Belcher, John D., Brügger-Verdon, Valérie, Adam, Jacqueline, Ruthsatz, Tanja, Bain, Joseph, Schu, Daniel, Ventrici, Lisa, Edler, Monika, Lioe, Hadi, Patel, Kalpeshkumar, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Wassmer, Andreas, Jain, Meena, Mischnik, Marcel, Pelzing, Matthias, Martin, Kirstee, Davis, Roslyn, Didichenko, Svetlana, Schaub, Alexander, Brinkman, Nathan, Herzog, Eva, Zürcher, Adrian, Vercellotti, Gregory M., Kato, Gregory J., Höbarth, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836474/
https://www.ncbi.nlm.nih.gov/pubmed/35160081
http://dx.doi.org/10.3390/jcm11030630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836474/
https://www.ncbi.nlm.nih.gov/pubmed/35160081
http://dx.doi.org/10.3390/jcm11030630

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