Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence

People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates inflammatory cell adhesion proteins on endothelial cells and circulating ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Gentinetta, Thomas, Belcher, John D., Brügger-Verdon, Valérie, Adam, Jacqueline, Ruthsatz, Tanja, Bain, Joseph, Schu, Daniel, Ventrici, Lisa, Edler, Monika, Lioe, Hadi, Patel, Kalpeshkumar, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Wassmer, Andreas, Jain, Meena, Mischnik, Marcel, Pelzing, Matthias, Martin, Kirstee, Davis, Roslyn, Didichenko, Svetlana, Schaub, Alexander, Brinkman, Nathan, Herzog, Eva, Zürcher, Adrian, Vercellotti, Gregory M., Kato, Gregory J., Höbarth, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836474/
https://www.ncbi.nlm.nih.gov/pubmed/35160081
http://dx.doi.org/10.3390/jcm11030630

Ejemplares similares

Ejemplares similares