Why Monoamine Oxidase B Preferably Metabolizes N-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step

Histamine levels in the human brain are controlled by rather peculiar metabolic pathways. In the first step, histamine is enzymatically methylated at its imidazole N(τ) atom, and the produced N-methylhistamine undergoes an oxidative deamination catalyzed by monoamine oxidase B (MAO-B), as is common...

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Detalles Bibliográficos
Autores principales: Maršavelski, Aleksandra, Mavri, Janez, Vianello, Robert, Stare, Jernej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836602/
https://www.ncbi.nlm.nih.gov/pubmed/35163835
http://dx.doi.org/10.3390/ijms23031910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836602/
https://www.ncbi.nlm.nih.gov/pubmed/35163835
http://dx.doi.org/10.3390/ijms23031910

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