Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness

(1) Background: Female sex is considered a risk factor for Intensive Care Unit-Acquired Weakness (ICUAW). The aim is to investigate sex-specific aspects of skeletal muscle metabolism in the context of ICUAW. (2) Methods: This is a sex-specific sub-analysis from two prospectively conducted trials exa...

Descripción completa

Detalles Bibliográficos
Autores principales: Engelhardt, Lilian Jo, Grunow, Julius J., Wollersheim, Tobias, Carbon, Niklas M., Balzer, Felix, Spranger, Joachim, Weber-Carstens, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836746/
https://www.ncbi.nlm.nih.gov/pubmed/35160299
http://dx.doi.org/10.3390/jcm11030846
_version_ 1784649753863127040
author Engelhardt, Lilian Jo
Grunow, Julius J.
Wollersheim, Tobias
Carbon, Niklas M.
Balzer, Felix
Spranger, Joachim
Weber-Carstens, Steffen
author_facet Engelhardt, Lilian Jo
Grunow, Julius J.
Wollersheim, Tobias
Carbon, Niklas M.
Balzer, Felix
Spranger, Joachim
Weber-Carstens, Steffen
author_sort Engelhardt, Lilian Jo
collection PubMed
description (1) Background: Female sex is considered a risk factor for Intensive Care Unit-Acquired Weakness (ICUAW). The aim is to investigate sex-specific aspects of skeletal muscle metabolism in the context of ICUAW. (2) Methods: This is a sex-specific sub-analysis from two prospectively conducted trials examining skeletal muscle metabolism and advanced muscle activating measures in critical illness. Muscle strength was assessed by Medical Research Council Score. The insulin sensitivity index was analyzed by hyperinsulinemic-euglycemic (HE) clamp. Muscular metabolites were studied by microdialysis. M. vastus lateralis biopsies were taken. The molecular analysis included protein degradation pathways. Morphology was assessed by myocyte cross-sectional area (MCSA). Multivariable linear regression models for the effect of sex on outcome parameters were performed. (3) Results: n = 83 (♂n = 57, 68.7%; ♀n = 26, 31.3%) ICU patients were included. ICUAW was present in 81.1%♂ and in 82.4%♀ at first awakening (p = 0.911) and in 59.5%♂ and in 70.6%♀ at ICU discharge (p = 0.432). Insulin sensitivity index was reduced more in women than in men (p = 0.026). Sex was significantly associated with insulin sensitivity index and MCSA of Type IIa fibers in the adjusted regression models. (4) Conclusion: This hypothesis-generating analysis suggests that more pronounced impairments in insulin sensitivity and lower MCSA of Type IIa fibers in critically ill women may be relevant for sex differences in ICUAW.
format Online
Article
Text
id pubmed-8836746
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88367462022-02-12 Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness Engelhardt, Lilian Jo Grunow, Julius J. Wollersheim, Tobias Carbon, Niklas M. Balzer, Felix Spranger, Joachim Weber-Carstens, Steffen J Clin Med Article (1) Background: Female sex is considered a risk factor for Intensive Care Unit-Acquired Weakness (ICUAW). The aim is to investigate sex-specific aspects of skeletal muscle metabolism in the context of ICUAW. (2) Methods: This is a sex-specific sub-analysis from two prospectively conducted trials examining skeletal muscle metabolism and advanced muscle activating measures in critical illness. Muscle strength was assessed by Medical Research Council Score. The insulin sensitivity index was analyzed by hyperinsulinemic-euglycemic (HE) clamp. Muscular metabolites were studied by microdialysis. M. vastus lateralis biopsies were taken. The molecular analysis included protein degradation pathways. Morphology was assessed by myocyte cross-sectional area (MCSA). Multivariable linear regression models for the effect of sex on outcome parameters were performed. (3) Results: n = 83 (♂n = 57, 68.7%; ♀n = 26, 31.3%) ICU patients were included. ICUAW was present in 81.1%♂ and in 82.4%♀ at first awakening (p = 0.911) and in 59.5%♂ and in 70.6%♀ at ICU discharge (p = 0.432). Insulin sensitivity index was reduced more in women than in men (p = 0.026). Sex was significantly associated with insulin sensitivity index and MCSA of Type IIa fibers in the adjusted regression models. (4) Conclusion: This hypothesis-generating analysis suggests that more pronounced impairments in insulin sensitivity and lower MCSA of Type IIa fibers in critically ill women may be relevant for sex differences in ICUAW. MDPI 2022-02-05 /pmc/articles/PMC8836746/ /pubmed/35160299 http://dx.doi.org/10.3390/jcm11030846 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Engelhardt, Lilian Jo
Grunow, Julius J.
Wollersheim, Tobias
Carbon, Niklas M.
Balzer, Felix
Spranger, Joachim
Weber-Carstens, Steffen
Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
title Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
title_full Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
title_fullStr Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
title_full_unstemmed Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
title_short Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
title_sort sex-specific aspects of skeletal muscle metabolism in the clinical context of intensive care unit-acquired weakness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836746/
https://www.ncbi.nlm.nih.gov/pubmed/35160299
http://dx.doi.org/10.3390/jcm11030846
work_keys_str_mv AT engelhardtlilianjo sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness
AT grunowjuliusj sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness
AT wollersheimtobias sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness
AT carbonniklasm sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness
AT balzerfelix sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness
AT sprangerjoachim sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness
AT webercarstenssteffen sexspecificaspectsofskeletalmusclemetabolismintheclinicalcontextofintensivecareunitacquiredweakness