Minocycline Counteracts Ectopic Calcification in a Murine Model of Pseudoxanthoma Elasticum: A Proof-of-Concept Study

Pseudoxanthoma elasticum (PXE) is an intractable Mendelian disease characterized by ectopic calcification in skin, eyes and blood vessels. Recently, increased activation of the DNA damage response (DDR) was shown to be involved in PXE pathogenesis, while the DDR/PARP1 inhibitor minocycline was found...

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Detalles Bibliográficos
Autores principales: Bouderlique, Elise, Nollet, Lukas, Letavernier, Emmanuel, Vanakker, Olivier M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837001/
https://www.ncbi.nlm.nih.gov/pubmed/35163765
http://dx.doi.org/10.3390/ijms23031838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837001/
https://www.ncbi.nlm.nih.gov/pubmed/35163765
http://dx.doi.org/10.3390/ijms23031838

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